The state of clinical trials of implantable Brain–Computer Interfaces

BCI Pioneer (and 2024 B-CRATOS Webinar participant) Ian Burkhart has recently co-authored a comprehensive review of clinical trials for implantable BCI in Nature Reviews Bioengineering!

Importantly, Ian and his co-authors not only review the history of BCI trials, but provide valuable insights regarding a pathway forward regarding patient ethics, a need for BCI standards, diversity in recruited volunteers, and other needs/barriers for progress.  The truly leave no stone unturned in covering everything from patient participants to research groups to technologies to the practicality of future clinical products.

And given Ian’s unique position as a former implantable BCI study participant, such perspective is invaluable for the field.  We expect this review to be a core resource for those wishing to better understand the history, present, and future of the field.

The review nicely compiles a list of emerging electrodes as of December 2023, and one notes the ever-growing number of data channels these devices aim to collect.  One can imagine that with multiple such devices implanted, we will see exponential increases in the amount and complexity of data collected in BCI of the future.   To take advantage of the full potential of such data, we will need next-generation wireless technologies capable of transmitting it for analysis and storage.  At B-CRATOS, we aim to develop such technologies to bring big data BCI systems to impactful real-world applications through improved integration within the body and to devices outside of it.  We also expect that by developing next-gen wireless technologies for implantable systems, patient acceptance, usability, and safety can be greatly improved over current systems.

 

Find the full article here!

B-CRATOS at Uppsala Cultural Night 2024

At Uppsala Cultural Night 2024, held on 14th September 2024, at the Anatomical Theatre in Gustavianum, Assoc. Prof. Robin Augustine from Uppsala University participated alongside other ongoing biomedical engineering researchers. He engaged with the public, presenting the B-CRATOS project and several questions  and interesting discussions followed.

Here you can find more information about the event:

https://www.uu.se/vetenskapsomrade/teknik-och-naturvetenskap/nyheter/arkiv/2024-09-25-manga-ville-se-framtidens-reservdelsmanniska-pa-kulturnatten

 

B-CRATOS at the 10th iteration of the 𝐈𝐄𝐄𝐄 𝐈𝐧𝐭𝐞𝐫𝐧𝐚𝐭𝐢𝐨𝐧𝐚𝐥 𝐂𝐨𝐧𝐟𝐞𝐫𝐞𝐧𝐜𝐞 𝐨𝐧 𝐁𝐢𝐨𝐦𝐞𝐝𝐢𝐜𝐚𝐥 𝐑𝐨𝐛𝐨𝐭𝐢𝐜𝐬 𝐚𝐧𝐝 𝐁𝐢𝐨𝐦𝐞𝐜𝐡𝐚𝐭𝐫𝐨𝐧𝐢𝐜𝐬 – 𝐁𝐢𝐨𝐑𝐨𝐛𝟐𝟎𝟐𝟒

Between 1 and 4 September 2024, the 10th IEEE International Conference on Biomedical Robotics and Biomechatronics held in Heidelberg, Germany. This conference aims to highlight the theoretical and practical challenges linked with the integration of robotics and mechatronics into medicine and biology.

In particular, our colleague Robinson Guachi from Scuola Superiore Sant’Anna participated with the paper “𝐌𝐞𝐜𝐡𝐚𝐧𝐢𝐜𝐚𝐥 𝐈𝐧𝐭𝐞𝐠𝐫𝐚𝐭𝐢𝐨𝐧 𝐨𝐟 𝐚 𝐒𝐞𝐧𝐬𝐨𝐫𝐢𝐳𝐞𝐝 𝐒𝐤𝐢𝐧 𝐢𝐧 𝐚𝐧 𝐀𝐧𝐭𝐡𝐫𝐨𝐩𝐨𝐦𝐨𝐫𝐩𝐡𝐢𝐜 𝐇𝐚𝐧𝐝: 𝐃𝐞𝐬𝐢𝐠𝐧 𝐩𝐢𝐩𝐞𝐥𝐢𝐧𝐞 𝐚𝐧𝐝 𝐭𝐞𝐬𝐭𝐬”. Here the summary of such an amazing presentation:

Human ability to manipulate and grasp objects relies heavily on tactile information from the skin, which the brain uses to guide motor actions. With advancements in neuroprosthetics, there is growing interest in integrating advanced tactile sensors into prosthetic hands. The paper presented during the conference, supported by the European B-Cratos project, proposes a systematic approach for designing and integrating triboelectric-based electronic skin (e-skin) into a prosthetic hand. It outlines the identification of technical requirements, material selection for soft skin, and optimization of sensor placement on the finger.  

Free webinar on Fat-IBC

On 12th September 2024, a free webinar will take place. Robin Augustine, coordinator of the B-CRATOS project, will deal with an important aspect of the project: Fat-IBC.

Join us to explore how this cutting-edge research paves the way for advancements in biomedical engineering and personal health monitoring systems!

You can find more information within the “events” section and register here!

A Joint Workshop is coming soon!

In February 2025, a significant joint workshop organised by three major leaders in Brain-Machine Interfaces will take place in Gardanne, France. The agenda will include speakers among the B-CRATOS partners and experts from the Institut Pasteur, the CEA-Clinatec and the EPFL.

Stay tuned as we will have the updated agenda and speakers finalised very soon!

B-CRATOS 3rd Newsletter

In May 2024, the third B-CRATOS newsletter was published.

Within these 6 articles you can:
🔸find more information about our last Consortium Meeting in LINKS Foundation
🔸 watch the entire version of our successful webinar on Clinical and User impacts on BCI with Paul Wanda (BlackRock Microsystems Europe), Mijail S.(Thomas Jefferson University in Philadelphia, Ian Burkhart and Scott Imbrie (BCI pioneers and advocates)
🔸 discover our impactful infographic and “meet our team” section
🔸 learn the following steps concerning the EIC Innovation Bootcamp 4.0
🔸 watch the interview of Robinson Guachi – Senior Research Fellow Mechanical Engineer – and Burim Kabashi – Research Fellow Electronic Engineer – in Scuola Superiore Sant’Anna concerning their incredible work on Mia Hand!

 

Discover more here!

 

Fourth Consortium Meeting in LINKS Foundation

In May 2024, we held our fourth in-person consortium meeting at LINKS Foundation in Turin. We shared updates and goals for each Work Package and discussed future plans for B-CRATOS. The meeting included general sessions, focused discussions on specific experiments and setups, and a tour of the LINKS Foundation.

Over the two days, we had productive discussions, and each partner left Italy with renewed energy and updated plans for B-CRATOS.

 

Special Webinar on BCI’s history

On 20th June 2024 a webinar with John Donoghue, Professor of Neuroscience and Engineering at Brown University took place. Watch such an interesting discussion of Brain-Computer Interfaces’ background (BCI) to discover the impact on #healthcare and daily living!

Not able to participate at it? Please find the replay here: Special webinar on BCI’s history with John Donoghue (youtube.com)

 

Free Webinar on Brain Computer Interface

Join us at our free webinar in March to a lively discussion of the impact of next generation brain computer interface technologies for various clinical applications with Paul Wanda from Blackrock Microsystems Europe!

Ethics within B-CRATOS

Why would ethics be relevant for a project such as B-CRATOS? Don’t we simply have to do our job, pave the way to innovation and not worry about any such kind of philosophical-like questions?

Definitely not.

On the contrary, if we look closely, our project has many reasons to take ethics into consideration: new technology and its future uses, use of animals for testing, a technology that is linked to the brain, raising many questions of safety and ethics. For us, this question is of prime importance, this is why we have an External Ethics Board supervising B-CRATOS. The Board gives us guidance and helps us understand what’s at stake. These insights are crucial to design the technology, and then to implement it, and improve it!

You can take a look at this video, in which our Ethics Board Chair, Nicola Di Stefano, explains why it matters.

If you wish to learn more about ethics in the field of technology and innovation, be sure to join us on October 27th at 4pm CEST: we organise a webinar to discuss the topic. It’s free! (register)